Make sure it ages well.
Finally, a physician-developed formula built to target what aging does to your brain.
Dr. Erik Hanson, MD
Psychiatrist
New Orleans, LA
Dr. Joseph Elfar, MD
Psychiatrist
Ridgewood, NJ
Dr. Amro Mahmoud, DO
Internal Medicine
San Diego, CA
Dr. Amanda Goldstein, MD
Psychiatrist
Los Angeles, CA
90-Day Risk-Free
Each ingredient earned its place because it had placebo-controlled human trials supporting a role in long-term brain health and healthy brain aging.
20mg B6 · 800mcg folate · 500mcg B12
Supports methylation and healthy homocysteine metabolism, processes involved in maintaining brain structure and function.*
In the two-year VITACOG trial, B-vitamin treatment slowed the rate of brain shrinkage by about 30% compared with placebo,1 with the strongest preservation seen in the brain regions most vulnerable to Alzheimer's-related damage.2
400mg magnesium glycinate · approximately 100mg elemental magnesium
Supports normal neurotransmission, cellular energy production, and the maintenance of healthy brain-cell signaling.*
In a placebo-controlled trial, supplementation with magnesium glycinate that rebalanced participants' calcium-to-magnesium ratio produced a 9.1% improvement in cognitive function in adults, nearly five times the improvement seen with placebo, with analysis suggesting part of the benefit was through changes in the genes related to Alzheimer's.3
Changes in overall cognitive function (MoCA)
Clinical trials using another bioavailable form (magnesium L-threonate) found similar cognitive improvements, suggesting the benefit comes from restoring brain magnesium levels, not from one proprietary form over another.3
1,000mg
Supports pathways involving nerve growth factor and the maintenance of healthy neural connections.*
Several placebo-controlled trials have reported improvements in cognitive measures with Lion's Mane. In one, scores improved during 16 weeks of supplementation and then declined after stopping, suggesting the benefit depends on continued use.5
Change in cognitive function (HDS-R)
Benefits faded after participants stopped taking it.
Participants taking Lion's Mane improved while placebo declined over nearly a year.
The Lion's Mane group improved faster than placebo on overall cognition.
5mg lithium orotate ≈ 0.2mg elemental lithium
Supports neuroprotective pathways involved in cellular resilience and healthy brain aging.
In a two-year placebo-controlled trial, the lithium group's memory scores stayed stable while the placebo group declined.6
Changes in memory recall (ADAS-Cog)
13 years later
Overall cognition (MMSE)
Finding words and verbal fluency (FAS)
CDR-Sum of Boxes stayed comparatively stable with lithium while the placebo group worsened.
A separate placebo-controlled trial also found less decline on a verbal-memory measure.
At a dose closest to Mentaid's, cognitive scores stayed stable while placebo declined — over 15 months.
Longer-term follow-up reported favorable differences in cerebrospinal-fluid tau measures.
Danish drinking-water studies found lower dementia rates in areas with higher lithium levels, and the authors concluded that residual confounding would likely underestimate the association.
Anyone who's concerned about their aging brain and wants to do something about it.
Take 2 capsules by mouth daily.
Lithium carbonate is a prescription medication used to treat bipolar disorder, and that's likely what comes to mind. But Mentaid contains lithium orotate, a different compound, which is available over the counter and has been used as a dietary supplement for decades.
For more information, see our Guide to Lithium Orotate.
At prescription doses (600-1800mg/day) and prescription forms (lithium carbonate), lithium has a narrow safety index, requires monitoring and lab draws. At supplemental doses (5mg/day) and supplemental forms (lithium orotate), lithium has a very different safety profile.
We formulated with conservatively and thoughtfully, with the form and dose amenable for daily use in mind.
A peer-reviewed toxicology study found that lithium orotate has been "marketed for decades as a supplemental source of lithium with few recorded adverse events." 1
Another peer reviewed source notes "there are no reported
cases of death or serious side effects in more than 40 years of lithium
orotate use in Europe and the U.S." 2
Another source notes "adverse effects have not been reported for low doses (lithium orotate 5 to 20 mg)." 3
For more information, see our Guide to Lithium Orotate.
Our formula contains 5 mg of lithium orotate, which provides approximately 200 micrograms of elemental lithium.
To put that into context, naturally occurring lithium in some drinking water sources can reach similar levels.
This is also lower than most other lithium orotate supplements on the market, which most commonly contain ~120 mg of lithium orotate, which provides 5mg of elemental lithium.
For more information, see our Guide to Lithium Orotate.
The CDC states: "You may have heard that if you have an MTHFR variant, you should avoid folic acid and should take other types of folate, such as 5-MTHF. However, this is not true. People with an MTHFR gene variant can process all types of folate, including folic acid."
This is also supported by the
American College of Obstetricians and Gynecologists and the American College of Medical Genetics and Genomics.
The best clinical studies evaluating B vitamins for cognitive support have used non-methylated forms, with success.
If you have a diagnosed metabolic disorder or specific medical concerns, consult your healthcare professional.
Mentaid is designed for consistent, daily brain support. Think of it less like a performance enhancer and more like a brain multivitamin. Some users notice changes. Others may not notice an immediate difference, but that doesn't mean it isn't working. The goal is to support your brain health as you age.
None. Every capsule contains only the active ingredients listed on the label, plus the capsule itself. We know that many tolerability issues people experience with supplements come from fillers and additives, not the ingredients themselves. That's why we kept it clean - just what's on the label and nothing more.
Yes. Mentaid is thoroughly tested at multiple stages of manufacturing. Every batch is tested for both purity and contaminants, and comes with a Certificate of Analysis.
Yes! Mentaid is manufactured in the state of Georgia in the United States.
Every ingredient in Mentaid was selected based on the strength and quality of available human clinical research. While many ingredients show promise in preclinical or animal studies, human outcomes do not always mirror early findings.
We prioritize well-designed human trials, safety and tolerability data, and how each ingredient functions within a cohesive formulation.
We continuously review emerging research and will refine the formula if and when new, high-quality human evidence supports it.
Yes. Mentaid is free from all 9 major allergens recognized by the FDA. Our formula contains no:
Our capsules are made from methylcellulose (a plant-based cellulose), and we use no fillers, binders, or excipients of any kind, just the active ingredients.
