Make sure it ages well.
Finally, a physician-developed formula built to target what aging does to your brain.
Dr. Erik Hanson, MD
Psychiatrist
New Orleans, LA
Dr. Joseph Elfar, MD
Psychiatrist
Ridgewood, NJ
Dr. Amro Mahmoud, DO
Internal Medicine
San Diego, CA
Dr. Amanda Goldstein, MD
Psychiatrist
Los Angeles, CA
90-Day Risk-Free
Each ingredient earned its place because it had placebo-controlled human trials supporting a role in long-term brain health and healthy brain aging.
20mg B6 · 800mcg folate · 500mcg B12
Supports methylation and healthy homocysteine metabolism, processes involved in maintaining brain structure and function.*
In the two-year VITACOG trial, B-vitamin treatment slowed the rate of brain shrinkage by about 30% compared with placebo,1 with the strongest preservation seen in the brain regions most vulnerable to Alzheimer's-related damage.2
400mg magnesium glycinate · approximately 100mg elemental magnesium
Supports normal neurotransmission, cellular energy production, and the maintenance of healthy brain-cell signaling.*
In a placebo-controlled trial, supplementation with magnesium glycinate that rebalanced participants' calcium-to-magnesium ratio produced a 9.1% improvement in cognitive function in adults, nearly five times the improvement seen with placebo, with analysis suggesting part of the benefit was through changes in the genes related to Alzheimer's.3
Changes in overall cognitive function (MoCA)
Clinical trials using another bioavailable form (magnesium L-threonate) found similar cognitive improvements, suggesting the benefit comes from restoring brain magnesium levels, not from one proprietary form over another.3
1,000mg
Supports pathways involving nerve growth factor and the maintenance of healthy neural connections.*
Several placebo-controlled trials have reported improvements in cognitive measures with Lion's Mane. In one, scores improved during 16 weeks of supplementation and then declined after stopping, suggesting the benefit depends on continued use.5
Change in cognitive function (HDS-R)
Benefits faded after participants stopped taking it.
Participants taking Lion's Mane improved while placebo declined over nearly a year.
The Lion's Mane group improved faster than placebo on overall cognition.
5mg lithium orotate ≈ 0.2mg elemental lithium
Supports neuroprotective pathways involved in cellular resilience and healthy brain aging.
In a two-year placebo-controlled trial, the lithium group's memory scores stayed stable while the placebo group declined.6
Changes in memory recall (ADAS-Cog)
13 years later
Overall cognition (MMSE)
Finding words and verbal fluency (FAS)
CDR-Sum of Boxes stayed comparatively stable with lithium while the placebo group worsened.
A separate placebo-controlled trial also found less decline on a verbal-memory measure.
At a dose closest to Mentaid's, cognitive scores stayed stable while placebo declined — over 15 months.
Longer-term follow-up reported favorable differences in cerebrospinal-fluid tau measures.
Danish drinking-water studies found lower dementia rates in areas with higher lithium levels, and the authors concluded that residual confounding would likely underestimate the association.
Anyone who's concerned about their aging brain and wants to do something about it.
Take 2 capsules by mouth daily.
The lithium you're thinking of is lithium carbonate, the prescription medication used to treat bipolar disorder at doses that require regular blood monitoring.
Mentaid does not contain that. Mentaid contains lithium orotate, a supplemental form sold over the counter for decades, at roughly one one-thousandth of a prescription dose.
Peer-reviewed sources report no deaths and no serious adverse events across more than 40 years of lithium orotate use in the US and Europe, and no documented adverse effects anywhere in the supplemental dose range. For scale, lithium toxicity is generally associated with an intake more than 2,600 times the amount in a daily serving of Mentaid.
Sources: peer-reviewed toxicology review, lithium orotate monograph.
For more information, see our Guide to Lithium Orotate.
Supplement labels make this confusing.
Our formula contains 5 mg of lithium orotate, which provides approximately 200 micrograms of elemental lithium.
To put that in context, someone drinking from a high-lithium water source can take in a comparable amount of elemental lithium over the course of a day without ever knowing it.
This is also lower than most other lithium orotate supplements on the market, which most commonly contain ~120 mg of lithium orotate, providing 5 mg of elemental lithium.
For more information, see our Guide to Lithium Orotate.
First, brain aging doesn't happen through one mechanism. It involves neuroplasticity, cellular resilience, neuronal growth and repair, signaling between neurons, and keeping neuroinflammation in check. Most brain supplements pick one of those angles, usually whichever ingredient is trending, and build the entire product around it. Mentaid was built by physicians who treat this clinically, and it covers all of them.
Second, the evidence bar. Mentaid's six ingredients were selected based on randomized controlled trials, the highest tier of clinical evidence. Much of what the supplement industry cites is observational research or studies run without a placebo group, which is the classic "correlation does not equal causation."
Mentaid is closer to a brain multivitamin than a performance enhancer.
Think about it the way you think about a statin, sunscreen, or a daily multivitamin. A statin doesn't produce a sensation. What it's doing to your arteries happens quietly, and you never feel any of it. Sunscreen is the same. So is a multivitamin. Nobody takes one and then judges it based on how they feel that afternoon.
Some people do notice something in the first several weeks, often that thoughts feel a little clearer, that names and details come back faster, or that they're sleeping better. Others won't notice a shift, and that's exactly what you'd expect from something working quietly in the background. Either way, it's doing the same thing: precision brain aging support.
Most people take Mentaid alongside their regular medications. As physicians, we see patients on long medication lists every day, and we built Mentaid with exactly those patients in mind.
Every ingredient and dose is printed on the label, with no proprietary blends. As always, with any specific questions about your health, talk to your doctor.
The work Mentaid is doing happens behind the scenes, every day, whether you feel it or not. Your brain is aging on that same schedule, so your support for it should be just as steady.
A subscription removes the decision. You save on every order, your price stays locked in for as long as you're subscribed, and you never hit a three-week gap because a bottle ran out on a busy month. The longer plans save more and arrive in a single box.
Yes, and you can do it however you like. Cancel or pause anytime from your account portal, or just email or call us and we'll handle it. No fees, no hoops, no retention script. We email you before each shipment so a charge never catches you off guard, and your pricing stays locked in for as long as you stay subscribed.
It's worth being precise about what "working" means here. Like a statin, sunscreen, or a multivitamin, Mentaid isn't built to produce a feeling you can check for. The work is happening quietly, and not noticing anything is the expected experience rather than evidence that nothing is happening.
That said, you should be able to try it without risk. Mentaid comes with a 90-day guarantee on your first bottle. If it isn't right for you for any reason, request a refund within 90 days of your first order and we'll refund the price of one bottle, minus a $10 processing and handling fee. There's nothing to ship back.
If you started on a 3-month or 6-month plan, the guarantee covers one bottle and you keep the rest. Refunds are limited to one per customer and apply only to your first order.
To start a request, email support@mentaidhealth.com with your order number, or reach us through our contact page. Once approved, refunds are applied to your original payment method within 5 to 10 business days. See our full refund policy for details.
“I'll be honest, I almost didn't buy Mentaid because of the lithium. I spent a lot of time reading about it before I finally ordered. I'm glad I did. I've been taking it for about 4 weeks and my thinking feels clearer, and I know that's not even the main goal of it. I don't know how else to describe it. I'm not someone who writes reviews but I wanted to say something for the people who are on the fence like I was.”
“I've been taking Mentaid for a month now and although I know it's supposed to be a long term play, I started noticing that I was thinking clearer and my memory was better after the first two weeks. I'm definitely going to be a long term Mentaid subscriber!”
“I know not everyone will feel better and that's not the main goal of Mentaid, but I feel so much better since starting. I feel sharper. My memory is better. My sleep is better. Even my wife has noticed. I would definitely recommend. And I've tried many of the other supplements on the market.”
“The word "dementia" seldom comes up in casual conversation; perhaps others are as intimidated as I by the thought of gradual, certain loss of what makes us ourselves. I believe using Mentaid, along with a brain-healthy lifestyle, might give me more time to be me. It's prevention, so I don't "notice" the effect, but I have read the underlying science, which suggests that Mentaid's components are at the cutting edge of our current knowledge. I don't miss a dose!”
“As a nurse practitioner, I absolutely love Mentaid. I recommend it to my patients and take it myself.”
“I wish we could have started sooner. After Alzheimer's devastated our family's lives, I bought Mentaid for me and my husband and we have been taking it since it came out.”
“So far, so good. I take two capsules before bed and, yes, it does help me sleep, but not long enough. However, when I wake, I do feel more refreshed and clear-headed than I felt before I started the Mentaid regimen. I believe my word recall has improved, as has my disposition.”
“The choice for me to start taking MENTAID was an easy one, but also a deliberate one. As part of my recovery from a TBI, I had already done my own research; and have been taking, lions mane, B12 & B6, folate, and magnesium glycinate for nearly a year. I was very excited to see a supplement that had all of these in one AND being made by a psychiatrist sealed the deal. I will be finishing my first bottle next week, and already have the second one here ready to go.”
“I tried other products for a year but then my doctor told me to try this instead.”
“I had been going back and forth on whether to try Mentaid because I was concerned about the lithium. But once I realized it had 5mg of LITHIUM OROTATE (not 5mg of LITHIUM) it made me feel more comfortable with the lithium but also made me trust Mentaid a lot more because these days it seems so many supplements are competing to just have the highest dose possible.”
“My wife has been taking it for 2 days. No noticeable changes. Probably to early to tell.”
“Mentaid has improved my mental homeostasis.After taking it for over a month, the changes were subtle, but have had a compounding effect. Taking it before bedtime, has helped my sleep, and my next morning wakefulness. Definitely recommend this product.”
“Since staring Mentaid, I have experienced a decrease in brain fog and mid-afternoon drowsiness, I sleep better with fewer interruptions of waking up and not being able to fall back asleep. Concentration and focus have improved!”
“Mentaid has really helped with my focus and energy without making me feel wired. Easy to take and no noticeable side effects so far. I’ll definitely keep using it.”
“I have had a great experience using Mentaid. In the time since I started I have better executive functioning. I feel like I'm able to complete my tasks more efficiently, I don't feel so much brain fog, and I'm able to organize my day better. It doesn't feel like stimulant energy, instead it feels like I'm able to think through complex situations and issues and maintain focus at the same time.”
“Wonderful product! No stinky smell or weird side effects! Just a true clean product. Dr. Hanson even replied to one of my questions in a timely manner. Exquisite service. I know this is supposed to help long term…but I’m definitely feeling better!”
“I really appreciate that Mentaid is a good 'ol fashioned capsule and doesn’t require mixing a drink or keeping bags of gummies on my countertop...which seems to be the latest supplement trend. I tried those but I always forgot or had to go out my way to remember. Capsules are simple and don't make a mess and I just add them to my daily pill container then don't have to think about it again.”
“My daughter bought Mentaid for me after she said it helped her and I'm glad she did.”
“I listened to a webinar on natural herbals that might slow memory loss. I was looking for a product that had all of them in one and my best friend who is a nurse sent me a link to Mentaid. I’m 57 but better late than never. Thank you, Sally.”
“I don't really leave reviews, but I have been so happy with Mentaid. The more I read about what's in it, the more I love it. Such a good product!”
“I will be a Mentaid customer for the rest of my life. Thanks, Patty Mills”
